BACKGROUND: DOUBLE GINGER TEA The Coronavirus disease-19 (COVID-19) primarily affects respiratory system leading to acute hypoxemic respiratory failure.Invasive mechanical ventilation has been a gold standard in the respiratory therapy of patients with acute respiratory distress syndrome (ARDS).It requires advanced ventilators, qualified intensivis
RNA-Binding Macrocyclic Peptides
Being able to effectively target RNA with potent ligands will open up a large number of potential therapeutic options.The knowledge on how to achieve this is ever expanding but an important question that remains open is what chemical matter is suitable to achieve this goal.The high flexibility of an RNA as well as its more limited chemical diversit
Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors
PFKFB3 is a bifunctional enzyme that modulates and maintains the intracellular concentrations of fructose-2,6-bisphosphate (F2,6-P2), essentially controlling the rate Art Set of glycolysis.PFKFB3 is a known activator of glycolytic rewiring in neoplastic cells, including central nervous system (CNS) neoplastic cells.The pathologic regulation of PFKF
Betaine and I-LG may have a predictive value for ATB: A causal study in a large European population.
PurposeTo analyze the causal relationship between 486 human serum metabolites and the active tuberculosis (ATB) in European population.MethodsIn this study, the causal relationship between human serum metabolites and the ATB was analyzed by integrating the genome-wide association study (GWAS).The 486 human serum metabolites were used as the exposur
Akt regulates drug-induced cell death through Bcl-w downregulation.
Akt is a serine threonine kinase with a major role in transducing survival signals and regulating proteins involved in apoptosis.To find new interactors of Akt involved in cell survival, we performed a two-hybrid screening in yeast using human full-length Akt c-DNA as bait and a murine c-DNA library as prey.Among the 80 clones obtained, two were id